A House on Fire follows brilliant doctor and mother Deborah Green (Stephanie March) who had the epitome of a picture-perfect life with two children, an adoring husband (Shaun Benson) and a beautiful house in an opulent neighborhood. But behind the curtain is a rocky marriage that includes Deb's difficult bedside manner, her inability to get along with other doctors and an abuse of pills and alcohol, major envy of her husband's successful medical career and his easy social manner, that takes a terrible turn and leaves her family and marriage in ruin.